Cryptographic techniques have the potential to enable distrusting parties to collaborate in fundamentally new ways, but their practical implementation poses numerous challenges. An important class of such cryptographic techniques is known as Secure Multi-Party Computation (MPC). Developing Secure MPC applications in realistic scenarios requires extensive knowledge spanning multiple areas of cryptography and systems. And while the steps to arrive at a solution for a particular application are often straightforward, it remains difficult to make the implementation efficient, and tedious to apply those same steps to a slightly different application from scratch. Hence, it is an important problem to design platforms for implementing Secure MPC applications with minimum effort and using techniques accessible to non-experts in cryptography. In this paper, we present the HACCLE (High Assurance Compositional Cryptography: Languages and Environments) toolchain, specifically targeted to MPC applications. HACCLE contains an embedded domain-specific language Harpoon, for software developers without cryptographic expertise to write MPC-based programs, and uses Lightweight Modular Staging (LMS) for code generation. Harpoon programs are compiled into acyclic circuits represented in HACCLE’s Intermediate Representation (HIR) that serves as an abstraction over different cryptographic protocols such as secret sharing, homomorphic encryption, or garbled circuits. Implementations of different cryptographic protocols serve as different backends of our toolchain. The extensible design of HIR allows cryptographic experts to plug in new primitives and protocols to realize computation. And the use of standard metaprogramming techniques lowers the development effort significantly. Harpoon programs are compiled into acyclic circuits represented in HACCLE’s Intermediate Representation (HIR) that serves as an abstraction over different cryptographic protocols such as secret sharing, homomorphic encryption, or garbled circuits. Implementations of different cryptographic protocols serve as different backends of our toolchain. The extensible design of HIR allows cryptographic experts to plug in new primitives and protocols to realize computation. And the use of standard metaprogramming techniques lowers the development effort significantly. We have implemented Harpoon and HACCLE, and used them to program interesting applications (e.g., secure auction) and key computation components of Secure MPC applications (e.g., matrix-vector multiplication and merge sort). We show that the performance is improved by using our optimization strategies and heuristics.